services

Nowadays, single gene disorders, especially rare disorders, have the difficulties to find the available laboratory for testing due to low number of affected persons. Therefore, most of the test require the laboratory outside the country which is costly. LMGG in the partnership to TCELS aims to develop the test as the benefit for people of Thailand using Thai technology and data analysis by specific Thai genome database. The available tests at LMGG include inherited heart, neurological, skin, blood, cancer and eye disorders. In addition, we can do custom genetic testing fitted with the clinician’s request if there is no available assay in the test catalogue.

It a common problem that the physician is facing with rare genetic diseases without available specific genetic testing. Sometimes, the gene of interest is rare and very few laboratories in the world perform the formal testing services. If some can do so, the cost is usually too high to afford. LMGG is seeing this problem then we develop the custom mutation testing to fit with the physician’s request. We are not only performing laboratory work, but also being careful in quality control to make the custom test to be highly reliable. Bioinformatic analysis based on the specific ethnicities is the basic principle of our work since people from different genetic backgrounds require different mode of analysis. Mainly, our medical consultants are keen to provide the clinical correlation related to the genetic result based on the clinical data provided by the requested physician. Clinical-molecular comment is definitely beneficial for the doctors, patients and families to make the decision and to plan for the next step of management.

Undiagnosed and unrecognized disease is the difficult situation for the clinicians. Some conditions are inherited and recurrent in the family. To date, the way to defeat genetic disease is to assist the couples with reproductive technology by either prenatal or preimplantation genetic diagnosis and genetic mutation is the key success for those techniques. Previously, decoding the genes suspected for any genetic disorders was done by DNA sequencing of the genes of interest. This means that the scientist has to spend the time to explore each gene, step-by-step. Larger gene, more sequencing reaction has to be done, also more times to spend in laboratory. If the scientists obtain nothing from the first gene or reaction, they are required to undergo working on the other genes that are suspicious. Hence, a lot of conditions with genetic heterogeneity may require more than 1 year to achieve the sequencing work. Clinical exome sequencing is the recent technology on Next-Generation sequencing platform that facilitates high-throughput works and able to perform sequencing of the coding region of thousand of genes simultaneously in the brief period of time. All lab works with thorough bioinformatics and clinical analyses can be completed within few months. This technology helps the clinicians to discover the predictive genetic markers for the patients and families effectively. However, the persons who require genetic testing using exome sequencing as the solution for their undiagnosed or unrecognized genetic condition are necessarily attend the genetic counseling session with genetic specialist to make sure that they are eligible for this technology.

Preimplantation genetic diagnosis (PGD) is a technique to identify the genetic defects in the embryos created through in vitro fertilization (IVF). The purpose of this technology is to assist reproduction in one or both biological parents carrying known genetic abnormalities. The mission of LMGG is to collaborate with the IVF center around Thailand and Southeast Asian region to establish this service for the couples at risk for single gene disorders. We are more than happy to help the reproductive specialist completing this task in both clinical and laboratory aspects.

LMGG understands the difficulty in genetic and genomic research in both government and private sectors due to the complicated research techniques methodology. Since LMGG is supported by GMP in a partnership to TCELS, we are keen to provide genomic technology as the methodology for your research using Next-generation and Capillary Sequencing. For more information, please contact 0 2668 4535